颗粒状炎作为皮下丸激素颗粒疗法的并发症
Meera H Patel1, Caitlin M Brumfiel2, Ilana Breen3
1Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, AZ; Meerapatel1@creighton.edu.
Skinmed
|August 27, 2023
概括
从长期注射中未溶解的丸激素引起了颗粒状胰腺炎和脂肪亡. 这种并发症发生了尽管经常排水和同时存在的黑色素瘤 in situ 在注射部位.
科学领域:
- 内分泌学 在内分泌学.
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 使用颗粒注射的外源性替代疗法 (TRT) 是治疗低子的常见方法.
- 与TRT颗粒注射相关的并发症,如感染和炎症,可能会发生.
- 保留未溶解的丸对皮下组织的长期影响尚未得到充分证实.
研究的目的:
- 报告一个罕见的细粒状泛炎和脂肪亡的病例,这是由于保留的丸激素造成的.
- 为了突出长期接受TRT颗粒注射的患者外体反应的潜力.
- 强调彻底检查和考虑持续注射部位并发症的因子的重要性.
主要方法:
- 一份病例报告详细介绍了一名51岁的男性患者,他有TRT颗粒注射病史.
- 临床检查显示皮下斑块与排水鼻通道和可疑的色素病变.
- 组织病理学分析活检组织和脱皮皮下脂肪,包括特殊染色 (PAS,Gram,AFB).
主要成果:
- 一个可疑为黑色素瘤的12毫米斑点在现场被确定并进行了活检.
- 脱皮组织的组织病理学显示了颗粒状透物,泛炎,脂肪亡和血红蛋白沉积.
- 六个未溶解的丸在手术期间被发现是注射部位的异物.
结论:
- 保留的丸可以导致显著的皮下炎症和组织损伤,模仿其他皮肤病.
- 这一案例强调了需要对长期TRT颗粒疗法的潜在并发症保持警,包括异物反应.
- 需要对这种并发症的管理和预防进行进一步的研究.
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