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多发性硬化症老年人的皮层厚度和认知能力

Dejan Jakimovski¹, Robert Zivadinov^2,3, Zachary Weinstock²

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St., Buffalo, NY, 14203, USA. djakimovski@bnac.net.

Journal of neurology

|August 27, 2023

概括

患有多发性硬化症的老年人认知障碍与特定大脑区域的稀薄有关,超出全球和乳头皮的变化. 这项研究突出了皮质结构在维持认知功能的作用.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
认知科学认知科学

背景情况:

患有多发性硬化症 (PwMS) 的老年人的结构性大脑变化及其对认知的影响尚不清楚.
老年PwMS (年龄≥50岁) 可能会经历认知衰退,但潜在的神经解剖学相关性需要进一步调查.

研究的目的:

调查全脑体积 (WBV),乳头体积和皮质厚度与老年PwMS的认知障碍 (CI) 之间的关联.
为了测试老年PwMS中CI与皮质稀释有关,除了全球和乳头神经退行之外,该假设.

主要方法:

101名老年PwMS接受了全面的认知评估 (MACFIMS,韦克斯勒记忆量表等). 和神经成像.
认知障碍 (CI) 被定义为在至少两个认知领域的表现>1.5 SD低于健康对照.
用SIENAX/FIRST来评估WBV和thalamic体积,用FreeSurfer来评估皮层厚度来评估大脑结构.

主要成果:

与认知保存 (CP) PwMS相比,CI PwMS显示左侧状,左侧下侧,左侧横侧和双侧上侧旋明显较薄.
在调整全球和乳头体积后,左侧状体和左侧状体的皮层厚度预测了CI状态.
特定的认知功能,如SDMT分数和口语流性,与左侧状骨的厚度和左侧状骨的厚度有关,分别.

结论:

多个大脑区域的皮层稀疏导致多发性硬化症老年人的认知障碍.
这些发现扩大了对神经退行变化的理解,这些变化与这一群体的认知能力下降有关.
这项研究强调了皮质结构对于在患有多发性硬化症的老年人中保持认知功能的重要性.

关键词:

衰老的衰老衰老的衰老认知障碍认知障碍是一种认知障碍.皮层稀释皮层稀释皮层稀释语言障碍语言障碍多发性硬化症是多发性硬化症.处理速度处理速度.

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