基于微阵列数据的癌细胞分类和基因选择,使用MOPSO算法
Mohammad Reza Rahimi1, Dorna Makarem2, Sliva Sarspy3
1Software Engineering, Qeshm Institute of Higher Education, Qeshm, Iran. m_rahimi17@yahoo.com.
Journal of cancer research and clinical oncology
|August 27, 2023
概括
这项研究引入了一种新的混合模型,使用多目标粒子群优化 (MOPSO) 来从微阵列数据中进行癌症分类. 通过有效地选择相关的基因,MOPSO方法显著提高了癌症分类的准确性.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 基因组学就是基因组学.
背景情况:
- 微阵列数据分析对于癌症研究和分类至关重要.
- 微阵列中的有限样本大小对准确的癌症分类构成了挑战.
- 有效的基因选择对于提高癌症分类准确度至关重要.
研究的目的:
- 开发一种新的混合模型来分类高维微阵列数据.
- 通过优化基因选择方法,提高癌症分类的准确性.
- 为应对癌症微阵列数据集有限样本大小的挑战.
主要方法:
- 一种混合模型,将多目标粒子群优化 (MOPSO) 与线性贝叶斯歧视分析相结合.
- 使用二进制向量表示,其中每个位对应于基因的选择状态.
- 使用分类算法评估基因组质量,以确定粒子适应性.
主要成果:
- 拟议的MOPSO算法应用于四个不同的癌症数据库.
- 在数据库中的分类准确度平均提高了25.84%.
- 在血液 (18.63%),肺 (24.25%),乳腺 (27.73%) 和前列腺 (32.80%) 癌症数据集中显示出显著的准确性改善.
结论:
- 基于MOPSO的方法有效地提高了癌症数据分类的准确性.
- 该模型通过识别和选择信息基因子集来减少冗余性.
- 这种方法通过考虑基因相关性和消除无关的基因来增强分类.
相关概念视频
Mouse Models of Cancer Study
5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K
Cancer-Critical Genes I: Proto-oncogenes
9.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.0K


