评估功能对大脑体积和痴呆风险的影响 英国生物银行
Xiaxuan Huang1, Shiqi Yuan1, Yitong Ling1
1Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
Archives of gerontology and geriatrics
|August 27, 2023
概括
降低功能显著增加痴呆风险,包括阿尔茨海默氏症和血管痴呆症. 功能下降也与大脑体积损失相关,突出显示了神经病理生理学联系.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 功能对整体健康至关重要,可能会影响认知功能.
- 以前的研究表明,病和痴呆症之间存在潜在联系,但潜在的机制需要进一步阐明.
研究的目的:
- 研究功能参数与患全因痴呆症 (ACD),阿尔茨海默病 (AD) 和血管痴呆症 (VD) 的风险之间的关联.
- 探索功能与大脑结构变化之间的关系,包括大脑体积.
主要方法:
- 利用考克斯比例危险回归和受限立方线分析,对来自452,996名英国生物库参与者的数据进行了分析.
- 评估功能,使用估计的膜过率 (eGFR) 和白蛋白与肌素比率 (ACR).
- 在40380名参与者的小组中,研究了功能和大脑磁共振指标之间的相关性.
主要成果:
- 功能恶化与所有原因痴呆症 (ACD) 的风险增加显著相关.
- 严重降低的eGFR (<30毫升/分钟/1.73米2) 与eGFR≥90毫升/分钟/1.73米2相比,显示了ACD和AD风险增加的最高值.
- 较高的ACR (>30 mg/mmol) 与较高的ACD风险有关. 功能下降与大脑总体体积减少和皮下缩相关.
结论:
- 功能下降,以较低的EGFR和增加的蛋白尿为标志,是痴呆症的重要危险因素.
- 观察到的关联得到了神经病理生理学证据的支持,这些证据表明与功能受损有关的大脑结构变化.
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