手术前的小呼吸道功能障碍与早期非小细胞肺癌的骨肌肉损失有关
Qing-Chun Jia1, Ye Niu1, Ling Qin2
1Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Clinical nutrition (Edinburgh, Scotland)
|August 27, 2023
概括
手术前的小呼吸道功能障碍 (SAD) 与早期非小细胞肺癌 (NSCLC) 患者手术后的骨肌损失有关. 在手术前确定SAD可以帮助预测和管理术后肌肉损失和并发症.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 手术后的骨肌 (SM) 损失与早期非小细胞肺癌 (NSCLC) 的预后不佳有关.
- 小呼吸道功能障碍 (SAD) 是一种常见的呼吸道问题,对其与早期NSCLC中术后SM损失的关联进行的研究有限.
研究的目的:
- 调查手术前小呼吸道功能障碍 (SAD) 和手术后骨肌肉 (SM) 损失在早期NSCLC患者之间的相关性.
- 确定术前SAD是否是术后SM损失和并发症的独立风险因素.
主要方法:
- 这是一项对348名在2017年1月至2020年12月期间接受手术的早期NSCLC患者 (I-IIIA阶段) 的回顾性研究.
- 骨肌肉指数 (SMI) 用CT扫描测量,在12个月内下降10.0%,被定义为过度的SM损失.
- 使用后勤回归分析来评估术前SAD和术后SM损失之间的关系,控制其他因素.
主要成果:
- 152名患者 (43.7%) 患有手术前的SAD,179人 (51.4%) 经历了手术后的SM损失.
- 患有SAD患者的SM损失发生率较高 (52.0%对34.9%,p=0.001) 和术后并发症.
- 手术前的SAD是术后SM损失的独立风险因素 (HR,2.465;p=0.009) 并与并发症相关 (HR,1.816;p=0.041).
结论:
- 手术前的小呼吸道功能障碍 (SAD) 与手术后的骨肌 (SM) 损失和早期NSCLC患者的并发症有显著联系.
- 对SAD进行手术前评估可能有助于对手术候选人的风险分层和有针对性的干预措施.
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