与醇相关的尿液变色:系统性文献综述
Ana Lasica1, Cinzia Cortesi2,3, Gregorio P Milani4,5
1Family Medicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
Pharmacology
|August 27, 2023
概括
普罗波可以引起绿色的尿液,这通常是良性的. 粉红色阴的尿液不太常见,可能与轻微的脏问题有关. 罕见的发毛,牛奶或便的绿色变色也发生.
科学领域:
- 麻醉学和药理学 麻醉学和药理学
- 临床毒理学 临床毒理学
- 患者安全 患者安全
背景情况:
- 普罗波是一种广泛使用的麻醉剂,可以引起不寻常的尿液和非尿道变色.
- 这些影响,包括绿色或粉红色的阴暗尿液和绿色的头发,牛奶,肝脏或便,没有得到充分的证据.
- 了解这些与propofol相关的变色的特征对于临床意识至关重要.
研究的目的:
- 为了调查由普罗波福尔诱导的尿液和非尿液变色的发生率和特征.
- 为了区分良性和可能涉及变色事件.
- 为了告知临床医生关于普罗波福的副作用的范围.
主要方法:
- 在主要数据库 (Excerpta Medica, MEDLINE/PubMed®, Web of Sciences) 进行了系统的文献搜索,截至2023年2月.
- 关键词包括"","","绿色","粉红色","阴暗"和"粉红色阴暗".
- 从个别病例报告中提取和分析数据.
主要成果:
- 从77份报告中确定了95例与普罗波相关的变色.
- 在54名患者中发生了绿色尿液变色,通常是在长时间输液 (≥24小时) 后,但有时在短时间 (≤3小时) 后.
- 粉红色阴的尿液 (32例) 与酸性尿液和尿酸增加有关,在2例中出现轻度急性损伤. 报告了9种非尿路绿色变色 (头发,牛奶,肝脏,便).
结论:
- 普罗波可以引起绿色的尿液,通常被认为是良性的.
- 粉红色的阴性尿液变色不太常见,可能与轻度急性损伤有关.
- 罕见的非尿液绿色变色的例子突出显示了普罗波福的多样化影响.
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