儿科大皮质子瘤:它们与小皮质子瘤有什么区别?
Chethan Yami Channaiah1, Saba Samad Memon1, Vijaya Sarathi2
1Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, India.
Neuroendocrinology
|August 27, 2023
概括
儿科库辛氏病 (CD) 来自大皮皮质热瘤 (MC) 与微皮质热瘤 (mc) 相比,具有不同的特征,如矮身和更高的BMI-SDS. 治疗结果相似,尽管MC可能需要更长时间的放射治疗才能缓解.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经内分泌学神经内分泌学
- 在瘤学瘤学.
背景情况:
- 儿科患者的库辛病 (CD) 是罕见的,特别是当由大皮皮质otropinoma (MC) 引起时.
- 关于由于MC而导致的儿科CD的特定特征和结果的数据有限,而不是微皮皮质瘤 (mc).
研究的目的:
- 确定患有MC的儿科CD患者的临床,生化,成像,管理和遗传特征.
- 为了将这些特征与患有mc的儿科CD患者的特征进行比较.
主要方法:
- 对32名患有CD和MC (≥10毫米瘤) 的儿科患者和65名患有MC (<10毫米瘤) 的儿科患者进行了回顾性分析.
- 收集的数据包括临床表现,生化标志物,成像发现,治疗策略和结果.
主要成果:
- 宏性皮质热瘤队列的BMI-SDS较高,神经眼科症状较多,身高较低,但斑纹和低血症比微性皮质热瘤队列少.
- 手术和放射治疗的缓解率相似,但MC的放射治疗后缓解的时间更长.
- 在儿科MC中,生殖系变异很少 (4%) .
结论:
- 库辛病中的儿科MC与特定的临床特征有关,包括质量效应症状,矮身,更高的BMI-SDS和独特的生物化学特征.
- 对于手术和放射治疗的治疗疗效在MC和MC之间是相似的,其中一个显著的例外是MC的放射治疗后延长的缓解时间.
- 通过生殖系变异的遗传倾向在儿科MC中不常见.
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