化疗相关的心脏功能障碍:定量心脏磁共振图像参数及其预后影响
Jinhee Kim1, Yoo Jin Hong2, Kyunghwa Han1
1Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
心脏MRI显示T2增加和化学治疗相关心脏功能障碍 (CTRCD) 的LV质量减少. 在CTRCD患者中,T2和晚期加多增强 (LGE) 预测主要不良心血管事件 (MACE).
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 化疗相关心脏功能障碍 (CTRCD) 是癌症患者的一个重大问题.
- 早期检测和CTRCD风险分层对于患者管理至关重要.
研究的目的:
- 量化分析心脏磁共振成像 (CMR) CTRCD的特征.
- 在CTRCD患者中探索CMR参数对主要心血管不良事件 (MACE) 的预后价值.
主要方法:
- 145名患有心力衰竭的癌症患者接受了3TCMR.
- 分析包括双心脏功能,原生T1/T2,细胞外体积分数 (ECV) 和晚期加多增强 (LGE).
- 考克斯回归被用来评估MACE预测.
主要成果:
- 61名患者有CTRCD. 61名患者有CTRCD. 与对照组相比,CTRCD患者的本源T1,ECV和T2值较高,索引LV质量较小.
- 在CTRCD组中,原生T1,ECV和T2显著更高.
- 增加的T2和量化的LGE与MACE独立相关.
结论:
- 定量CMR参数可以评估心肌细胞在CTRCD中的变化.
- 在CTRCD中观察到T2增加和LV质量减少,甚至在严重功能障碍之前.
- T2和LGE是CTRCD中MACE的潜在独立预后因素.
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