在丹麦队列中暴露于空气中的多双和2型糖尿病
Laura Deen1, Alice Clark2, Karin Sørig Hougaard3
1Department of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, Denmark; Department of Public Health, The Faculty of Health Sciences, University of Copenhagen, Denmark.
Environmental research
|August 27, 2023
概括
室内空气中多双 (PCB) 的更高暴露与2型糖尿病 (T2D) 的风险略有增加有关. 然而,没有发现明确的剂量反应关系,这表明解释时需要谨慎.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 以前的研究将高化PCB与2型糖尿病 (T2D) 联系起来.
- 关于与室内空气中普遍存在的低化PCB相关的T2D风险的数据有限.
- 这项研究调查了室内PCB暴露与T2D发病率之间的关联.
研究的目的:
- 评估住宅室内空气暴露在多二 (PCB) 和2型糖尿病 (T2D) 的发生率之间的关系.
- 调查PCB暴露和T2D风险的潜在剂量反应关系.
主要方法:
- 使用基于登记的"室内空气中的PCB对健康的影响" (HESPAIR) 队列,包括51,921名丹麦居民.
- 通过结合搬迁历史与外推空气测量来评估PCB暴露.
- 通过丹麦登记 (1977-2018) 识别T2D病例,并使用Cox回归分析数据.
主要成果:
- 总共有2737例T2D病例被确定.
- 暴露于≥3300 ng/m3 PCB ×年显示T2D的风险略高 (HR 1.15,95% CI 1.02-1.30).
- 与参考组相比,较低的累积PCB暴露水平没有显示T2D风险增加.
结论:
- 在室内空气中PCB暴露较高时,观察到T2D风险的边际增加.
- 没有明显的暴露-反应关系是显而易见的.
- 结果需要谨慎解释和在独立研究中得到确认.
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