大麻安全性考虑:制定潜在的可接受每日摄入量值和建议的食补充剂使用的摄入量上限
Rayetta G Henderson1, Melissa Vincent2, Brianna N Rivera3
1ToxStrategies LLC, Wilmington, NC, USA.
Regulatory toxicology and pharmacology : RTP
|August 27, 2023
概括
新的研究确立了大麻 (CBD) 隔离物的安全每日摄入限量. 这些建议旨在指导消费者,并在不同的暴露场景中确保包括儿童和成人在内的不同人群的安全.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 由于消费者越来越多地使用大麻制品,因此需要基于证据的安全指南.
- Cannabidiol (CBD) 是一种主要的麻衍生化合物,在市场上越来越多的存在.
- 由于没有确定的CBD口服摄入量上限,这可能会给公众健康带来潜在的风险.
研究的目的:
- 制定基于证据的建议,对大麻素 (CBD) 隔离物的口服上限摄入量.
- 为一般人群确定可接受的每日摄入量 (ADI).
- 确定特定成年人群的食补充剂的上限摄入量 (UL).
主要方法:
- 对CBD安全性发表的人体临床试验的系统审查.
- 在动物模型中分析符合指导方针的毒性研究.
- 基于确定的人类和动物数据的剂量反应评估.
主要成果:
- 根据肝脏效应,为一般人群确定了0.43 mg/kg-bw/d (30 mg/d为70 kg的成年人) 的潜在可接受每日摄入量 (ADI).
- 根据动物生殖效应,针对健康成年人的食补充剂确定了70 mg/d的潜在上限摄入量 (UL).
- 基于肝脏效应,针对健康成年人提出了100 mg/d和160 mg/d的替代UL,考虑了特定的排除.
结论:
- 该研究为确定CBD分离物的安全消费水平提供了关键数据.
- 建议适用于不同人群,包括敏感人群和健康成年人群.
- 这些发现支持知情的消费者选择和CBD产品的监管指导.
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