果提取物通过调节胆汁酸输肝循环来保护肝脏内胆固醇形成
Shasha Qin1, Jingzhuo Tian1, Yong Zhao1
1Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimen Nei Ave, Beijing, 100700, China.
Journal of ethnopharmacology
|August 27, 2023
概括
花提取物 (GE) 通过调节胆汁酸 (BA) 代谢来缓解胆汁性质. GE上调Cyp8b1以减少BA合成并促进BA分泌,改善肝脏健康和肠肝循环.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 自然产品 化学 化学
背景情况:
- 胆固醇症是胆固醇性肝病的关键特征,可以发展为末期肝病.
- 传统上,Gardeniae Fructus (GF) 用于肝脏疾病,可能对胆酸 (BA) 代谢产生影响.
- 在改善胆固醇的精确机制和目标的GF仍然不清楚.
研究的目的:
- 调查来自GF的花提取物 (GE) 的机制,以改善由α-纳非化酸盐 (ANIT) 诱导的胆固醇性肝损伤.
- 阐明转基因对胆酸代谢和肠肝循环的影响.
主要方法:
- 鼠被用GE或obeticholic acid (OCA) 治疗,并使用ANIT诱导胆固醇症.
- 分析包括生物化学分析,肝病理学,BA代谢学,转录学和qRT-PCR.
- 评估了与BA合成和运输相关的基因表达.
主要成果:
- GE剂量依赖减弱的ANIT诱导胆固醇和肝损伤.
- 转录基因分析显示,转基因会影响初级胆酸 (PBA) 生物合成和胆汁分泌途径.
- GE上调了Cyp8b1以抑制BA合成,以及Fxr/Oatp1以促进BA分泌,改善肠肝循环.
结论:
- 在老鼠中,GE有效地改善了ANIT诱导的肝毒性和胆固醇病变.
- 该机制涉及通过Cyp8b1上调抑制BA合成,并通过Fxr/Oatp1.1增强BA分泌.
- 它改善了胆汁酸的肠肝循环,为胆固醇性肝脏疾病提供了治疗潜力.
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