发现血清粉样蛋白A蛋白家族的深层进化根源
Marcel Zámocký1, Peter Ferianc2
1Laboratory of Phylogenomic Ecology, Institute of Molecular Biology, Slovak Academy of Sciences, Dúbravská cesta 21, SK-84551 Bratislava, Slovakia; Department of Inorganic Chemistry, Faculty of Natural Sciences, Comenius University Bratislava, Mlynská dolina, Ilkovičova 6, SK-84215 Bratislava, Slovakia.
International journal of biological macromolecules
|August 27, 2023
概括
动物血清粉样蛋白A (SAA) 脂蛋白家族有古老的起源,在细菌中发现类似的SAA样序列. 确定了肠道细菌和动物之间的横向基因转移事件,揭示了深层次的进化联系.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 生物化学 生化学
背景情况:
- 血清粉样蛋白A (SAA) 脂蛋白家族在动物中得到保存.
- SAA蛋白的进化史和物种间关系尚未完全理解.
- 最近在细菌基因组中发现了类似的SAA样序列.
研究的目的:
- 为了调查SAA蛋白家族的深层进化起源.
- 在细菌基因组中识别和表征非常相似的SAA类序列.
- 探索涉及SAA基因的细菌和动物之间的潜在水平基因转移事件.
主要方法:
- 使用最大概率和邻近连接方法进行了家族遗传学分析.
- 基因树的重建基于来自不同动物类和细菌基因组的128个完整的SAA序列.
- 在SAA蛋白家族中对保存的序列图案和结构折叠进行比较分析.
主要成果:
- 证明了保存的动物SAA无脂蛋白家族的深层进化起源.
- 在某些肠道细菌的基因组中确定了非常相似的SAA类序列.
- 在肠道细菌和非脊椎动物之间发现了SAA基因水平基因转移的证据.
- 标志着保存的序列图案和SAA家族成员中常见的四个α螺旋捆结构.
结论:
- SAA蛋白家族具有深刻的进化历史,对理解动物和细菌基因进化有意义.
- 横向基因转移在细菌和动物之间SAA类基因的分布中发挥了作用.
- 保存的结构和序列特征表明SAA蛋白在各种生物体中具有基本的生物学作用.
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