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循环中的可溶性IL-6受体与斑块炎症有关,但与动脉样硬化严重程度和心血管风险无关
Andreas Edsfeldt1, Isabel Gonçalves2, Isa Vigren3
1Department of Clinical Sciences Malmö, Lund University, Sweden; Department of Cardiology, Skåne University Hospital, Sweden; Wallenberg Center for Molecular Medicine, Lund University, Sweden.
Vascular pharmacology
|August 27, 2023
概括
高水平的IN-6 (IL-6) 与心血管疾病 (CVD) 和动脉样硬化风险的增加有关. 可溶性IL-6受体 (sIL-6R) 不是可靠的心血管疾病风险标志物,但反映了斑块炎症.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 残留心血管疾病 (CVD) 风险与持续的血管炎症有关.
- 洲际蛋白-6 (IL-6) 是炎症的关键调解剂和潜在的治疗点.
- IL-6通过直接与受体结合或通过可溶性IL-6受体 (sIL-6R) 发挥其作用.
研究的目的:
- 研究IL-6和sIL-6R通路与心血管疾病 (CVD) 风险之间的关联.
- 评估IL-6/sIL-6R与动脉样硬化,动脉硬和内皮功能之间的关系.
- 确定sIL-6R在斑块炎症中的作用.
主要方法:
- 通过近距离延伸试验,分析来自三大前性队列 (MDC,SUMMIT VIP,CPIP) 的血样本中的IL-6和sIL-6R.
- 对发生的心血管事件 (心肌梗塞) 的长度随访和临床结果的评估.
- 动脉样硬化斑块的免疫组织化学和生物化学分析.
主要成果:
- 血IL-6水平升高与心肌梗塞风险增加显著相关 (HR 2.60 [2.08-3.25]).
- 高IL-6与增加动脉样硬化,动脉硬性和内皮功能受损相关.
- 溶性IL-6受体 (sIL-6R) 与心血管疾病风险或血管功能没有独立的关联,但与斑块炎症有关.
结论:
- 血IL-6是心血管事件和相关血管病理的显著风险标志物.
- 可溶性IL-6受体 (sIL-6R) 不是整体心血管疾病风险的可靠指标.
- sIL-6R与斑块炎症的关联表明IL-6信号在动脉样硬化中起着复杂的作用.
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