相关实验视频

Updated: Jul 18, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

⁶⁸Ga-FAPI-04正子发射断层扫描区分恶性病变与18F-FDG-激烈的结直肠病变

Chengfang Shangguan¹, Chen Yang², Zhaopeng Shi³

¹Department of Oncology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

International journal of radiation oncology, biology, physics

|August 27, 2023

概括

标有68 (Ga) 标签的纤维细胞激活蛋白抑制剂4 (FAPI-04) 定子发射断层扫描-计算机断层扫描 (PET-CT) 有效地区分良性和恶性结肠直肠病变. 这种新型的放射追踪器在改善结直肠癌的诊断准确性方面表现有前途.

科学领域:

核医学就是核医学.
在瘤学瘤学.
放射化学放射化学是指辐射化学.

背景情况:

F-氧糖 (F-FDG) 定子发射断层扫描 - 计算机断层扫描 (PET-CT) 在良性和恶性结直肠病变中显示出高吸收率,限制了其特异性.
纤维细胞激活蛋白 (FAP) 在各种癌症中过度表达,使得针对FAP的成像成为潜在的诊断工具.
标记Ga的纤维细胞激活蛋白抑制剂4 (FAPI-04) 是一种用于FAP成像的新型放射追踪剂.

研究的目的:

评估Ga-FAPI-04 PET-CT在区分良性与恶性结肠直肠病变中的有效性,这些病变具有高F-FDG吸收.
在临床前结直肠瘤模型和人类患者中评估Ga-FAPI-04 PET-CT的诊断性能.

主要方法:

开发一种由阿佐西甲/德克斯硫酸盐 (AOM/DSS) 诱导的小鼠结直肠瘤模型.
在小鼠模型和22名患者中应用双标记物Ga-FAPI-04和F-FDG PET-CT.
对PET-CT检测结果与肠镜检查,组织病理学,FAP免疫组织化学 (IHC) 和放射自拍的相关性. 在172名确诊结直肠病变的患者中进行了FAP IHC.

主要成果:

在大鼠模型中,Ga-FAPI-04 PET-CT 准确地区分了恶性和良性炎症病变.
在患者中,在没有结直肠癌的22名胃癌患者中,在8名患者中观察到F-FDG摄取,但Ga-FAPI-04 PET是负的.
在18个F-FDG激发性病变中,85.1%的恶性病变 (80/94) 是FAP阳性,而只有20.5%的良性或前恶性病变 (16/78) 显示Ga-FAPI-04吸收较弱. 炎症性病变和腺瘤没有干扰成像.

结论:

68 Ga-FAPI-04 PET-CT在区分良性和恶性结直肠病变方面表现出高准确性.
与F-FDG PET-CT相比,FAPI-04 PET-CT在诊断结直肠癌方面提供了更好的特异性.
这种辐射追踪器对结直肠癌的临床诊断具有重大潜力.

更多相关视频

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

相关概念视频

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...