细胞外囊泡作为王国间通信的新型媒介
Jumin Huang1, Xuanrun Wang1, Ziming Wang1
1Cancer Centre, Faculty of Health Sciences, Universty of Macau, Macao Special Administrative Region of China; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Macao Special Administrative Region of China.
Cytokine & growth factor reviews
|August 27, 2023
概括
细菌和植物的细胞外囊泡 (EV) 是细胞间关键的通讯器. 这些纳米粒子在药物输送和调节肠道微生物群方面显示出治疗潜力,影响宿主健康和草药疗效.
科学领域:
- 微生物学和生物技术
- 细胞生物学和细胞间通信
- 药理学和药物输送 药理学和药物输送
背景情况:
- 细胞外囊泡 (EVs) 是各种细胞类型分泌的纳米级,脂质双层封闭的颗粒,作为细胞间信使.
- 细菌EV (BEV) 范围在20-400纳米之间,含有核酸,蛋白质,脂质甘油和短链脂肪酸 (SCFA).
- 植物性EVs (PEVs),包括来自草药的EVs,与肠道微生物群相互作用.
研究的目的:
- 审查细菌EVs (BEVs) 和植物EVs (PEVs) 的生理作用.
- 讨论肠道细菌,宿主新陈代谢和EVs介导的草药之间的交叉交流.
- 突出电动汽车在各种应用中的治疗潜力.
主要方法:
- 文献综述侧重于细菌和植物EVs的组成和功能.
- 分析EV在细菌群体动态,宿主免疫调节和肠道微生物群的恒常性中的作用.
- 探索EV在疫苗开发,癌症免疫疗法和草药治疗中的应用.
主要成果:
- BEV含有生物活性分子,包括质量检测,影响细菌防御,社区形成和宿主免疫力.
- PEVs可以被肠道微生物群吸收,影响其组成和整体平衡.
- 电动汽车与肠道微生物群生态系统中的沟通中介有关.
结论:
- 细胞外囊泡在肠道微生物群中充当关键的沟通媒介.
- BEV和PEV在药物输送和调节宿主微生物相互作用方面具有显著的治疗潜力.
- 动植物药物是提高草药疗效和开发新疗法策略的有希望的途径.
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