在未知病因的早期慢性病中肠道微生物群的轻微变化
Ditsayathan Banjong1,2, Thatsanapong Pongking1,2, Na T D Tran3
1Biomedical Science Program, Graduate School, Khon Kaen University.
Microbes and environments
|August 27, 2023
概括
早期慢性病 (CKD),特别是未知的病因 (CKDu),显示肠道微生物群的变化和较低的血清乙酸盐水平. 泰国的这些发现可能会为CKD预防策略提供信息.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 肠道失调和改变的短链脂肪酸 (SCFA) 已在晚期慢性病 (CKD) 中已知.
- 在早期CKD,特别是未知病因的CKD中,肠道微生物组和SCFA概况仍然不太清楚.
- 在早期阶段调查这些变化对于潜在的早期干预至关重要.
研究的目的:
- 在早期CKD患者 (1-3阶段) 中调查肠道微生物组合和血清SCFA概况.
- 专门研究患有潜在疾病 (UD) 和未知病因的CKD (CKDu) 的患者之间的差异.
- 确定潜在的早期生物标志物,用于CKD的发展和进展.
主要方法:
- 研究包括72名无寄生虫的参与者:健康对照 (HC),UD,CKD-UD和CKDu组.
- 使用下一代测序对聚合便DNA进行分析的肠道微生物组合.
- 血清SCFA度通过气色谱-质谱法测量.
主要成果:
- 在健康组和所有患者组 (UD,CKD-UD,CKDu) 之间,微生物的丰富程度有显著差异.
- 与HC和CKD-UD组相比,CKDu组中的[Eubacterium]_coprostanoligenes_group显著更为丰富.
- 与HC组相比,所有患者组 (UD,CKD-UD,CKDu) 的血清乙酸盐度显著降低.
结论:
- 早期的CKDu与肠道微生物组的微妙变化有关.
- 在早期CKD患者中观察到血清乙酸盐水平的显著降低,包括CKDu患者.
- 这些发现突显了肠道微生物组和SCFA变化的潜在作用在早期CKD病原体中,并建议预防策略的途径.
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