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循环瘤细胞是胆囊腺癌患者预后不佳的独立危险因素

Cheng Yan¹, Yangyan Xiao², Weichang Zhang¹

¹Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Annals of surgical oncology

|August 27, 2023

概括

循环瘤细胞 (CTC) 是胆囊腺癌患者术后预后不佳的重要指标. 在手术前检测CTC可以帮助量身定制治疗策略,以获得更好的结果.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
分子诊断学分子诊断

背景情况:

胆囊腺癌具有显著的临床挑战,预后可变.
评估预后标志物对于优化手术切除后患者管理至关重要.

研究的目的:

为了评估循环瘤细胞 (CTC) 的预后价值,在经过手术切除后患有胆囊腺癌的患者.
确定CTC检测是否可以预测癌症特异性存活率 (CSS) 和无病存活率 (DFS).

主要方法:

研究了一组101名胆囊腺癌患者的队列,这些患者在2018年至2021年期间接受了切除.
使用CanPatrol®技术检测和量化了循环瘤细胞 (CTC).
癌症特异性存活率 (CSS) 和无病存活率 (DFS) 用日志级和考克斯回归模型进行了分析.

主要成果:

在操作组的13.64%和非操作组的61.54%中检测到CTC.
在手术组中,CTC阳性患者的CSS (5.0 vs. 9.5个月) 和DFS (2.8 vs. 5.0个月在III阶段) 显著较短.
多变量分析确定了阳性CTCs作为差CSS的独立风险因素,与淋巴透和没有R0切除或辅助化疗一起.

结论:

阳性CTC是胆囊切除后胆囊腺癌患者预后不佳的独立预测因素.
术前CTC检测为制定个性化治疗策略提供了宝贵的指导.
这一发现强调了CTC作为风险分层和治疗计划的生物标志物的潜力.

关键词:

通过使用CanPatrol®技术.循环瘤细胞 (CTCs) 是一种循环瘤细胞.胆囊腺癌胆囊腺癌胆囊腺癌预测预后预测预测手术切除手术切除的方法

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