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母亲脱氧尼瓦伦醇暴露与分娩结果之间的不良关联:中国的一项前性队列研究

Tianqi Tan¹, Tingting Chen², Wenwen Zhu¹

¹Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China.

|August 27, 2023

概括

母亲暴露于脱氧尼瓦伦醇 (DON) 与胎儿生长的减少有关. 孕妇超过DON的临时最大可容忍每日摄入量 (PMTDI) 的后代出生时体重和长度较低,并增加了对妊娠年龄 (SGA) 较小的风险.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
生殖健康生殖健康

背景情况:

脱氧尼瓦伦醇 (DON) 是一种普遍存在的真菌毒素,已知会导致动物的胎儿生长迟缓.
关于DON对孕妇和人类胎儿发育的影响的数据有限.

研究的目的:

调查怀孕期间母亲暴露于Deoxynivalenol (DON) 和不良分娩结果之间的联系.
评估胎儿生长限制的风险,包括降低出生体重,长度,以及与妊娠年龄相比较小 (SGA),与DON摄入量相关.

主要方法:

总DON (tDON) 和自由DON (fDON) 的母体尿度在第二个三个月内被测量.
计算了DON的临时每日摄入量 (PDI),统计模型评估了与出生体重,身长和SGA风险的关联.

主要成果:

平均DON摄入量为0.7μg/kg体重,其中35.9%的女性超过PMTDI.
较高的母体tDON和fDON度与降低出生体重显著相关.
超过DON的PMTDI与较低的出生体重和长度以及后代患SGA的风险更高有关.

结论:

孕妇在怀孕期间暴露于Deoxynivalenol (DON) 与降低出生体重和长度有关.
研究结果表明,DON暴露可能导致胎儿生长失速.
建议在孕妇中减少DON暴露,以减轻对胎儿的不良结果.

关键词:

出生的体重出生时的体重.群组研究是一项群组研究.脱氧尼瓦伦烯 (deoxynivalenol) 是一种除氧化烯 (deoxynivalenol) 的一种.孕妇孕妇孕妇孕妇对于妊娠年龄来说,小的

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