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重复的闭头轻度创伤性脑损伤诱导的炎症与 nociceptive 敏感化有关

Tyler Nguyen1,2, Natalie Nguyen1, Ashlyn G Cochran1

  • 1Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN, USA.

Journal of neuroinflammation
|August 27, 2023
PubMed
概括

重复的轻度创伤性脑损伤 (mTBIs) 会导致长期的炎症和疼痛. 使用MCC950抑制NLRP3炎症酶激活可降低小鼠的这些炎症性疼痛信号.

关键词:
在Caspase-1中,炎症 炎症是一种炎症.无感觉性敏感化 (nociceptive sensitization) 是一种对知觉的提高.mTBI mTBI 的意思是什么

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Nociception01:44

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Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
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