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在口腔癌中与MiRNA相关的转移:移动和动

Meghdad Eslami¹, Saba Khazeni¹, Xaniar Mohammadi Khanaghah¹

¹Department of oral and maxillofacial surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Cancer cell international

|August 27, 2023

概括

口腔癌转移是由非编码RNA驱动的,包括微RNA (miRNA),长非编码RNA (lncRNA) 和圆形RNA (circRNA). 这些分子调节癌症传播的关键步骤,提供潜在的治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

口腔癌是一个日益增长的全球健康挑战,死亡率和发病率不断增加.
癌症转移是一种复杂的,多步骤的过程,涉及细胞入侵,迁移和血管输出.

研究的目的:

审查有关非编码RNAs (miRNAs, lncRNAs, circRNAs) 和它们在调节口腔癌转移中的作用的文献.
探索miRNA,lncRNA和circRNA相互作用在口腔癌细胞传播中的机制.

主要方法:

从2000年到2023年,对科学数据库 (谷歌学者,Scopus,PubMed) 进行全面的文献搜索.
对专注于口腔癌转移中的非编码RNA网络 (miRNA-mRNA, lncRNA-miRNA-mRNA, circRNA-miRNA-mRNA) 的研究进行分析.

主要成果:

微RNAs (miRNAs) 是口腔癌转移的关键调节者,通过向转移相关基因,作为瘤抑制剂或瘤基因.
长非编码RNAs (lncRNAs) 和圆形RNAs (circRNAs) 调节口腔癌转移,通常通过与miRNAs作为竞争的内源RNAs进行相互作用.
这些非编码RNAs影响关键的转移过程,如上皮细胞-介质细胞过渡,迁移,入侵和殖民.

结论:

非编码RNAs,特别是miRNAs,在控制口腔癌细胞入侵,迁移和转移方面发挥着重要作用.
了解lncRNA/circRNA-miRNA-mRNA网络,可以了解口腔癌传播的分子机制.
非编码RNAs代表了开发针对口腔癌转移的新型治疗策略的有希望的目标.

关键词:

循环的RNA是循环的RNA.长的非编码RNA是什么?转移转移转移转移这是一个微型RNA.没有编码的RNAs.

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