早期生活后的重复性和强迫性行为-与减少的长链脂类物种相关的疼痛
Alexandra Vogel1, Timo Ueberbach2, Annett Wilken-Schmitz1
1Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University, Frankfurt, Germany.
Cell & bioscience
|August 27, 2023
概括
在小鼠中,早期的疼痛会导致长期的疼痛过敏和强迫行为. 这些变化与脂代谢的改变有关,表明对慢性疼痛和精神病理学的倾向.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 早期的疼痛暴露会影响神经发育,增加慢性疼痛的风险.
- 开发了一种使用Advillin (Avil) 促销器驱动的通道罗多普辛-2 (ChR2) 表达在非体感应器中的新型光遗传学小鼠模型,以研究生命早期疼痛 (ELP).
研究的目的:
- 研究早期疼痛对感官处理,行为和神经生物学的长期影响.
- 探索脂体代谢在调解早期疼痛影响中的潜在作用.
主要方法:
- 在生命早期 (产后第1-5天) 对表达Advillin的感受体的光遗传刺激.
- 多电极阵列记录用于皮层刺激性评估.
- 用于突触基因表达分析的RNA测序.
- 行为测试 (知觉,焦虑,社交互动,空间记忆,强迫行为) 和脂质学研究.
主要成果:
- 早期的疼痛导致皮质过度刺激和关键突触基因的减少表达.
- 暴露于早期疼痛的成年小鼠对热量和机械刺激表现出持续的过敏,感官神经元流量增加.
- 观察到强迫性行为,包括重复的鼻和夸张的,并与大脑和血中的基美林水平降低有关.
结论:
- 早期的疼痛可能会使个人倾向于慢性疼痛和强迫性精神病理学.
- 脂代谢的改变可能是这些长期影响的关键机制.
- 研究结果表明,早期疼痛,脂蛋白变化以及成和精神疾病等疾病之间存在潜在联系.
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