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人类衍生菌的抗炎疗效Streptococcus salivarius对周期性病原体诱导的炎症
Dong-Heon Baek1, Sung-Hoon Lee1
1Department of Oral Microbiology and Immunology, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea
Journal of microbiology and biotechnology
|August 28, 2023
概括
Salivary Streptococcus G7 酸 (LTA) 降低了由周周病原体引起的炎症. 这种有益的细菌可以通过抑制炎症性细胞因子产生和病原体分子结合来帮助预防牙周炎.
科学领域:
- 口腔微生物学 口腔微生物学
- 免疫学 免疫学 免疫学
- 益生菌的研究研究.
背景情况:
- Salivary Streptococcus 是一种具有益生菌潜力的有益的口腔细菌.
- 周周病原体通过脂多糖 (LPS) 和脂铁醇酸 (LTA) 触发炎症.
研究的目的:
- 为了研究S. salivarius G7脂铁醇酸 (LTA) 的抗炎作用.
- 阐明S. salivarius G7 LTA调节由周周病原体LPS和LTA引起的炎症的机制.
主要方法:
- 人类单细胞细胞被S. salivarius G7表面分子,周期性致病原体LPS和LTA治疗.
- 使用实时PCR和ELISA量化细胞因子表达.
- 使用光标记的病原体分子,流动细胞计和对CD14和LPS结合蛋白 (LBP) 相互作用的分析进行了结合试验.
主要成果:
- S. salivarius G7表面分子没有诱导炎症性细胞因子表达.
- S. salivarius G7 LTA显著抑制了由周期性病原体LPS和LTA诱导的炎症性细胞因子.
- S. salivarius G7 LTA 阻断了病原体 LPS 和 LTA 的细胞结合.
- S. salivarius G7 LTA抑制了病原体LPS和LTA与CD14和LBP的结合.
结论:
- S. salivarius G7 LTA表现出强大的抗炎特性,可以对抗带病原体诱导的炎症.
- S. salivarius G7 LTA通过抑制病原体分子与宿主细胞和相关蛋白质结合而起作用.
- S. salivarius G7显示出作为预防牙周炎的益生菌的潜力.
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