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血时间是突然感觉神经听力损失的诊断生物标志物,并预测了预后

Junying Chen^1,2, Yunhua Yang³, Shuna Huang^2,4

¹Central laboratory, Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Ear, nose, & throat journal

|August 28, 2023

概括

血时间 (TT) 可以诊断突然的感觉神经听力损失 (SSNHL) 并预测患者的结果. 提升的TT水平与SSNHL相关,并影响治疗的有效性,使其成为一个有价值的预后生物标志物.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
血液学血液学血液学
诊断生物标志物诊断生物标志物

背景情况:

突然感觉神经听力损失 (SSNHL) 是一种复杂的疾病,需要有效的诊断和预后工具.
血栓激素时间 (TT) 是一种实验室测试,测量血液凝结所需的时间.

研究的目的:

调查血红时间 (TT) 作为突然感觉神经听力损失 (SSNHL) 的诊断生物标志物的潜力.
评估TT在预测诊断为SSNHL的患者的预后方面的实用性.

主要方法:

一项涉及61名SSNHL患者和65名对照者的病例控制研究.
采用二进制物流回归和接收机操作特征 (ROC) 分析来评估TT的诊断和预后能力.
根据听力恢复,患者被分为有效和无效的治疗组.

主要成果:

与对照组相比,SSNHL患者表现出明显延长的TT (19.11 ± 1.12s与17.58 ± 2.18s相比,P < .001).
TT与SSNHL (OR 1.769,P <.001) 独立相关,最佳诊断截止值为17.65s (AUC 0.773).
与无效治疗组 (19.43 ± 1.09s,P = .018) 相比,有效治疗组 (18.76 ± 1.06s) 的较短TT表明预后值,截止时间为19.85s.

结论:

血时间 (TT) 显示出作为SSNHL的诊断生物标志物的潜力.
TT与SSNHL独立相关,并作为患者预后和治疗反应的重要预测因素.

关键词:

诊断生物标志物的生物标志物预后预后预后这是一项回顾性研究.突然的感觉神经神经听力损失.血栓凝血时间 (Thrombin Time) 是指

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