单细胞/巨细胞调解了抑郁对克罗恩病的影响
Xin Zhang1, Pengbo Wang2, Yi Yang1
1Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Scandinavian journal of gastroenterology
|August 28, 2023
概括
抑郁症通过改变单细胞/巨细胞,对克罗恩病 (CD) 有负面影响. 这些免疫细胞显示细胞减少和炎症增加,恶化CD的预后.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
背景情况:
- 抑郁症与克罗恩氏病 (CD) 风险增加和较差的结果有关.
- 单细胞和巨细胞是关键的免疫细胞,涉及到抑郁症和CD的发病.
研究的目的:
- 调查单细胞/巨细胞是否调解抑郁症对CD的影响.
- 检查单细胞/巨细胞细胞和细胞因子生产的变化.
- 评估对CD4+T淋巴细胞分化和肠上皮质屏障功能的影响.
主要方法:
- 从CD患者中分离的单细胞/巨细胞 (抑郁症与非抑郁症).
- 评估了细胞形成,细胞因子产生 (TNF-α,IL-6,IL-1β) 和T细胞亚群分化 (Th1,Th2,Th17,Treg).
- 评价了上皮屏障完整性 (Caco-2细胞) 和紧结蛋白表达.
主要成果:
- 患有抑郁症的CD患者表现出单细胞/巨细胞消化酶的减少和高水平的炎症性细胞因子 (TNF-α,IL-6,IL-1β).
- 来自抑郁症患者的单细胞促进了Th1/Th17分化,并抑制了Treg细胞.
- 患有抑郁症的患者的巨细胞损害了上皮质屏障功能,减少了TEER和紧结蛋白.
结论:
- 单细胞/巨细胞功能障碍有助于抑郁症对CD的负面影响.
- 机制包括减少细胞分裂,增加炎症,扭曲的T细胞分化,以及损害表皮屏障完整性.
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