在二线救援化疗后复发或耐火性扩散大B细胞淋巴瘤的可移植患者的临床结果:一项回顾性研究
Yu Yagi1, Yusuke Kanemasa1, Yuki Sasaki1
1Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Cancer medicine
|August 28, 2023
概括
对二线救援化疗的化学敏感性对于复发或耐火性扩散大B细胞淋巴瘤 (DLBCL) 的患者至关重要. 救援化疗的响应者表现出更好的生存率和更好的后续治疗结果,如CAR T细胞疗法或ASCT.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 复发性或耐火性扩散性大B细胞淋巴瘤 (R/R DLBCL) 预后不佳.
- 对于未能接受一线救援化疗的患者来说,最佳的治疗策略仍未确定.
研究的目的:
- 评估R/R DLBCL患者进行二线救援化疗的化学敏感性预后意义.
- 评估二线救援化疗后潜在的治愈治疗后的结果.
主要方法:
- 对接受二线救援化疗的可移植R/R DLBCL患者进行回顾性单中心研究.
- 对反应率,整体存活率 (OS) 和进展到治愈治疗 (ASCT,CAR T细胞疗法,allo-SCT) 的分析.
主要成果:
- 第二线救援化疗的总体反应率为39.5%.
- 响应二线救援化疗的患者的生存寿命明显更长.
- 对二线救援化疗的反应显著增加了继续ASCT或CAR T细胞治疗的可能性.
- 之前的化学敏感性,而不是之前的化疗线的数量,是生存的重要预测因素.
- 在ASCT和CAR T细胞疗法之间没有显著的OS差异.救援后化疗反应.
结论:
- 化学敏感性是R/R DLBCL患者的生存结果的关键因素,特别是那些接受CAR T细胞治疗的患者.
- 自主造血干细胞移植 (ASCT) 和CAR T细胞疗法都是成功的二线救援化疗后的可行选择.
更多相关视频
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
08:05Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
7.9K
相关概念视频
Bone Marrow Sampling and Transplants
359
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
359
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Tissue Transplantation
396
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
396
