当代左心室辅助装置支持患者的参数中的循环节律
L Numan1, M Wösten1,2, M Moazeni3
1Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
Artificial organs
|August 28, 2023
概括
大多数HeartMate3左心室辅助装置患者表现出功率的昼夜节律,早上显著增加. 这一发现对于开发先进的监测算法来改善患者的治疗结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 医疗器械技术 医疗器械技术
背景情况:
- 左心室辅助器件 (LVAD) 需要监测算法来提高患者的治疗结果.
- 之前的研究在HeartWare (HVAD) 参数中确定了昼夜节律.
- 在HeartMate3 (HM3) 设备中的循环节律模式仍然没有特征,阻碍了算法开发.
研究的目的:
- 在HeartMate3 (HM3) 设备参数中描述昼夜模式.
- 调查HM3参数与心率 (HR) 昼夜模式之间的关系.
主要方法:
- 在1-2周内从18名患者收集高频HM3数据 (1-2小时间隔).
- 使用可穿戴生物传感器测量心率 (HR).
- 分析了使用热图和24小时等号配合的昼夜模式;计算了幅度关系的斯皮尔曼相关性.
主要成果:
- 与流量和脉动性指数 (PI) 相比,HM3功率的患者间变异性较低.
- 83%的HM3患者表现出显著的昼夜节律功率,其中一个早晨的峰值 (p < 0.001-0.04).
- 所有患者在HR表现出显著的昼夜节律 (p < 0.001-0.02);功率和HR昼夜幅度之间没有发现相关性 (r=0.32,p=0.19).
结论:
- 大多数HeartMate3患者在参数中表现出昼夜节律.
- 收集高频参数数据对于未来的预测算法开发至关重要.
- 早期发现并发症可以通过基于昼夜数据的先进监测算法来促进.
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