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在老鼠中,母体感染 Porphyromonas gingivalis 牙周病导致后代的认知能力下降

Eri Ishida¹, Hisako Furusho², Ting-Yi Renn³

¹Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Frontiers in pediatrics

|August 28, 2023

概括

孕妇在怀孕期间感染 Porphyromonas gingivalis 会损害后代的认知功能. 这种感染导致子女大脑中的神经炎症和神经退行,突显了对母亲感染控制的需要.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
发展生物学发展生物学

背景情况:

Porphyromonas gingivalis (P. gingivalis) 是一个主要的牙周病原体,与子宫内感染有关.
宫内感染会增加后代患神经系统疾病的风险.
母乳牙周炎对后代大脑发育的影响尚不清楚.

研究的目的:

研究母体P. gingivalis感染对后代行为和大脑组织学的影响.
阐明母亲牙周炎与后代神经变化之间的关系.

主要方法:

一个孕期小鼠模型被用来研究P. gingivalis感染.
对后代的行为进行了评估,使用逐步的被动回避和开放现场测试.
对脑组织进行了神经元细胞计数,炎症标志物和质细胞激活的分析.

主要成果:

母亲P. gingivalis感染显著降低了后代的认知功能 (获取试验延迟).
在整个后代大脑中检测到P. gingivalis,特别是在海马体.
在海马体和杏仁体中观察到神经炎症和神经退行,增加了微质和星球细胞标记物,减少了神经元标记物.

结论:

孕期孕妇P. gingivalis感染会对后代的认知功能产生负面影响.
在后代大脑中观察到的神经退行和神经炎症可能是母体传播的P. gingivalis感染的后果.
在怀孕前或怀孕期间消除孕产妇的P. gingivalis感染对于保持健康的后代大脑发育至关重要.

关键词:

葡萄牙牙牙病 Porphyromonas gingivalis 这种虫子是星球细胞是星球细胞.母亲暴露的母亲暴露.微质细胞中的微质细胞神经系统疾病神经系统疾病牙周炎是指牙周炎的一种疾病.

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