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早期青春期与儿童肥胖风险之间的关联:系统性审查和元分析
Yongfu Song1, Yibu Kong1, Xiaofei Xie1
1Department of Pediatrics, Hospital Affiliated to Changchun Traditional Chinese Medicine University, Changchun, China.
Frontiers in pediatrics
|August 28, 2023
概括
早期青春期增加了女孩的肥胖风险,但不是男孩. 这一元分析强调过早的青春期是女性肥胖的重要风险因素,强调了早期干预的必要性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 公共卫生
- 肥胖问题研究研究
背景情况:
- 早发性青春期 (早发性青春期) 是一种比平均年龄更早开始青春期发育的情况.
- 早期青春期和肥胖风险之间的关系,特别是在不同性别的人群中,需要进一步研究.
- 了解这种关联对于早期发现和治疗儿童肥胖至关重要.
研究的目的:
- 评估早期青春期与儿童各种形式肥胖的风险之间的潜在关联.
- 为了区分女孩和男孩的风险.
- 为考虑早期青春期作为肥胖的独立风险因素提供证据.
主要方法:
- 在PubMed,EMBASE,Web of Science和Cochrane图书馆的系统文献搜索.
- 对早期青春期肥胖的几率比率 (OR) 和95%置信区间 (CI) 的元分析.
- 使用基于异质性的固定效应或随机效应模型 (P > 0.1 和 I2 ≤ 50%),通过漏斗图表和埃格尔测试评估出版偏差.
主要成果:
- 少女早期青春期与更高的整体肥胖风险有显著的关联 (OR = 1.98;95% CI:1.76-2.24).
- 过早青春期的女孩患有一般肥胖 (OR = 2.03),中心肥胖 (OR = 1.96) 和超重 (OR = 2.03) 的风险增加.
- 在男孩中,过早的青春期与一般肥胖,中心肥胖或超重的风险增加无关.
结论:
- 女孩早期的青春期与显著增加的肥胖风险有关.
- 男孩早期的青春期似乎与肥胖风险的增加无关.
- 早期青春期应该被认为是女孩肥胖的独立风险因素,需要临床关注.
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