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甲状腺疾病综合征在MIS-C的预后作用:来自单中心观察研究的结果
Michele Fastiggi1, Alessandra Meneghel1, Joaquin Gutierrez de Rubalcava Doblas2
1Pediatric Rheumatology Unit, Department of Woman and Child Health, University of Padova, Padova, Italy.
Frontiers in pediatrics
|August 28, 2023
概括
甲状腺疾病综合征 (ESS) 在患有多系统炎症综合征 (MIS-C) 的儿童中很常见. 低fT3水平预测严重疾病,并指导患者管理.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺病综合征 (ESS) 涉及低血清自由三甲状腺素 (fT3) 与正常/低TSH和fT4.
- ESS发生在急性疾病中,如败血症,糖尿病酸性脂肪酸症和心脏手术后.
- 儿童多系统炎症综合征 (MIS-C) 是一种可能导致严重后果的急性疾病.
研究的目的:
- 评估ESS对MIS-C患者疾病严重程度的预测作用.
- 评估ESS标志物与MIS-C.中的临床参数之间的关联.
- 了解MIS-C.中的ft3水平的预后价值.
主要方法:
- 一个单一中心的观察性研究包括连续的MIS-C患者.
- 收集了临床和实验室数据,包括甲状腺功能测试.
- 统计分析涉及曼-惠特尼U测试和斯皮尔曼的罗相关性.
主要成果:
- 在42名MIS-C患者中,有86%的人接受了ESS.
- 较低的fT3水平与重症监护室 (ICU) 的入院和严重的心肌抑郁 (EF <45%) 相相关.
- fT3显示了与Hb,血小板,射出分数,CRP,BNP,IL-2受体和S-100蛋白的相关性.
结论:
- 在MIS-C.的急性阶段,ESS是一个频繁的,短暂的发现.
- 严重降低的fT3水平是严重疾病过程的显著预后因素.
- 监测fT3可能会影响MIS-C患者的治疗和临床结果.
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