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工程植物衍生纳米纤维促进瘤治疗:自然生物活性加上药物控制释放平台
Xiaohang Chen1,2, Shuaiqi Ji1,2, Yuxiang Yan1
1Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, People's Republic of China.
International journal of nanomedicine
|August 28, 2023
概括
植物衍生的纳米纤维 (PDNVs) 显示出天然的抗瘤活性,并且可以被设计为精确的药物输送. 这些纳米纤维提供了一个有希望的平台,通过改善药物向和减少副作用来增强癌症治疗方法.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 瘤是一个重大的全球健康挑战,推动了对先进癌症治疗的需求.
- 目前的治疗方法面临的局限性包括药物耐药性,针对性差,以及严重的副作用.
- 精确向药物递送系统的需求很高,以克服这些挑战.
研究的目的:
- 审查植物衍生纳米纤维 (PDNVs) 的天然抗瘤特性.
- 探索工程 PDNV 作为癌症治疗新型药物输送平台的潜力.
- 讨论PDNVs临床应用的挑战和未来方向.
主要方法:
- 对PDNV及其治疗应用研究的文献综述.
- 分析PDNV的组成,结构和生物活动.
- 对外部修饰策略的评估,以提高PDNV的疗效.
主要成果:
- PDNVs对瘤细胞表现出内在的抗增殖和前亡作用.
- PDNVs可以调节瘤微环境并逆转药物耐药性.
- 工程 PDNV 证明了改善的稳定性,瘤向性和细胞吸收药物输送.
结论:
- PDNV具有作为直接抗瘤剂和药物输送载体的巨大潜力.
- 外源性修改可以优化PDNV以获得更好的治疗结果.
- 需要进一步的研究来将PDNV转化为有效的临床癌症治疗方法.
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