综合多组学揭示了素酸在改善免疫应激 brojlers 的生长性能和免疫功能方面的有益作用
Huawei Liu1, Xuemin Li1, Kai Zhang1
1College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266109, China.
Animal nutrition (Zhongguo xu mu shou yi xue hui)
|August 28, 2023
概括
酸 (CGA) 通过改善肠道健康和调节关键代谢途径,增强肉的生长和免疫力. 这项研究揭示了CGA在商业家禽生产中减轻压力的潜力.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
背景情况:
- 强化肉生产可能会导致免疫应激.
- 众所周知,酸 (CGA) 影响肠道微生物群,屏障功能和的免疫反应.
研究的目的:
- 通过多组学方法阐明使用德甲 (DEX) 诱导的压力下肉中CGA的免疫调节机制.
- 研究CGA对生长性能,肠道健康和免疫功能的影响.
主要方法:
- 一个2x2的因数设计,有240只肉,包括CGA补充剂 (0或500毫克/公斤) 和DEX注射.
- 多omics分析包括微生物组测序,代谢学和蛋白质学.
- 评估生长表现,阴茎形态,屏障功能和免疫标志物.
主要成果:
- 在接受DEX治疗的肉中,CGA改善了生长,头形态,屏障功能和免疫功能.
- CGA增加了肠道微生物群的多样性,短链脂肪酸,并丰富了"pyruvate发酵到butanate"的途径.
- 蛋白质组学和代谢学确定了PPAR和MAPK通路的CGA介导调节,增加了促进健康的蛋白质和代谢物的表达.
结论:
- 补充CGA可以提高DEX处理的肉的生长性能和免疫功能.
- 通过调节肠道微生物群组成和关键信号通路 (PPAR,MAPK),CGA发挥其益处.
- 这些发现为CGA在改善家禽肠道健康和免疫功能方面的作用提供了新的见解.
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