慢性异常性低酸血症患者的高发病率和死亡率:全国范围的队列研究
Kyoung Jin Kim1, Ji Eun Song2, Ji Hyun Kim2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Frontiers in endocrinology
|August 28, 2023
概括
慢性异常性低度血症 (CIH) 影响所有年龄段的患者,并增加并发症和死亡的风险. 这项研究揭示了双模式年龄分布,并突出了CIH患者的长期健康结果.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 遗传学 遗传学 是一个
背景情况:
- 慢性异常性低度血症 (CIH) 是一种罕见的疾病,流行病学数据有限.
- 了解CIH患病率和长期结果对于患者管理至关重要.
研究的目的:
- 确定韩国CIH的流行率和长期健康结果.
- 调查CIH患者的流行病学特征,包括年龄分布和性别差异.
主要方法:
- 使用了韩国健康保险审查和评估索赔数据库 (2003-2018).
- 确定了154名患有非二次性,非性低血症的患者.
- 与1540名低酸血症患者和年龄,性别和指数年相匹配的对照进行了比较.
主要成果:
- 观察到双模年龄分布,儿童早期 (1-4岁) 和成年 (40-70岁) 的峰值.
- 发病率呈现出非显著的趋势,从每百万人中0.24到0.30 (2003-2018).
- 在CIH患者中,并发症 (aHR 2.17),死亡率 (aHR 3.26) 和住院 (aHR 2.49) 的风险显著增加.
结论:
- 这是韩国首个关于CIH的全国性研究.
- CIH呈现出双模年龄分布,没有显著的性别偏好.
- CIH与健康不良结果的风险大幅增加有关,包括死亡率和住院治疗.
相关概念视频
Chronic Kidney Disease II: Clinical Manifestations
29
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
29
Chronic Kidney Disease III: Interprofessional Care
42
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
42
Peritoneal Dialysis III: Nursing Management
45
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
45
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
41
Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
41
Nephrotic Syndrome I : Introduction
9
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
9
Pulmonary Hypertension: Classification and Pathogenesis
222
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
222


