在多囊性卵巢综合征中,甲福明与螺旋和单独甲福明相结合:元分析
Huamin Zeng1, Ying Zhang1,2, Sikai Huang1
1Department of Endocrinology and Metabolism, The Third Affiliate Hospital of Guangzhou Medical University, Guangzhou, China.
Frontiers in endocrinology
|August 28, 2023
概括
甲胺和螺旋的联合治疗有效地降低了多囊性卵巢综合征 (PCOS) 患者的体重指数 (BMI) 和总 (TT). 这种PCOS治疗方法在长时间使用时显示出改善的胰岛素耐药性和空腹血糖 (FBG),没有增加副作用.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种异质的内分泌疾病,其病因不明,缺乏特定的治疗方法.
- 胰岛素敏感剂美特福明和抗雄激素spironolactone可能为PCOS管理提供互补的好处.
研究的目的:
- 通过元分析评估PCOS联合甲福明和螺旋乳治疗的疗效和安全性.
- 为了比较组合治疗与单独甲胺对各种PCOS相关参数的影响.
主要方法:
- 对截至2022年12月16日发表的随机对照试验 (RCT) 进行了元分析.
- 搜索的数据库包括PubMed,Embase,Scopus,Cochrane图书馆,CNKI,CBM,Wangfang和VIP. 这些数据库的搜索范围包括:
- 评估的结果:体重指数 (BMI),宫症得分,LH,FSH,TT,FBG,HOMA-IR,以及不良事件.
主要成果:
- 组合疗法显著降低了BMI和TT.
- 没有观察到对 hirsutism 评分,LH 或 FSH 的显著影响.
- 在超过6个月的治疗时间内,FBG和HOMA-IR的显著减少被观察到.
- 副作用的发生率与甲福明单一治疗相比较.
结论:
- 甲胺加上螺旋可能比单独的甲胺更有效地降低PCOS中的BMI和雄激素.
- 组合疗法并没有显著改善 hirsutism 评分或淋巴激素水平.
- 较长的治疗周期 (>6个月) 增强了FBG和胰岛素抵抗的益处.
- 需要进一步的研究来确定最佳的治疗持续时间.
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