在COVID-19大流行期间使用较短的治疗方案对MDR-TB的结果进行前性研究
G Sravan Kumar1, P Sameena2, V Karthik1
1Department of Pulmonary Medicine, Governement General and Chest Hospital, Affilated to Osmania Medical College, Hyderabad, Telangana, India.
Journal of family medicine and primary care
|August 28, 2023
概括
较短的药物治疗方案显示,多耐药结核病 (MDR-TB) 患者的成功率为65.2%,恶心和吐等副作用可控. 改善营养状况和基线药物敏感性测试 (DST) 对于更好的结果至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 印度在2020年报告了66,225例多药耐药/耐利结核病 (MDR/RR-TB) 病例.
- 在检测到的MDR/RR-TB病例中,有85%的患者开始接受治疗.
- 75%的治疗病例在诊断时开始使用较短的药物治疗方案.
研究的目的:
- 评估MDR-TB患者较短药物疗程的疗效.
- 估计在较短的疗程中使用的药物的不良影响.
主要方法:
- 未来的,以机构为基础的研究.
- 包括135名确诊的MDR-TB患者.
- 排除了肺外MDR-TB和使用特定药物 (SLI) 超过一个月的患者.
主要成果:
- 较短疗程的治疗成功率为65.2%.
- 常见的不良事件包括恶心 (39.3%) 和吐 (34.8%).
- 不太常见的不良反应是听力损失 (8.9%) 和甲状腺功能低下 (0.2%).
结论:
- 尽管有COVID-19的挑战,较短的疗程取得了与以前的研究相似的治疗成功.
- 副作用主要是轻微的胃肠道问题和老年患者的听力损失.
- 低BMI和未知的药物耐药性与不成功的结局有关,强调需要营养支持和改进药物敏感性测试 (DST).
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