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Updated: Jul 18, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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在内分泌治疗耐药性前列腺癌中,AR基因拷贝数和结构复杂性的共同进化

Andrej Zivanovic1, Jeffrey T Miller2, Sarah A Munro2

  • 1Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.

NAR cancer
|August 28, 2023
PubMed
概括

由于雄激素受体 (AR) 的重新激活,化抵抗性前列腺癌 (CRPC) 进展. 我们发现,染色体外DNA (ecDNA) 驱动复杂的AR基因变异和拷贝数增加,导致内分泌疗法耐药性.

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