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探索Shigella疫苗优先级和偏好:来自低收入和中等收入环境中混合方法研究的结果
Jessica A Fleming1, Nikki Gurley1, Sophia Knudson1
1PATH, Seattle, 2201 Westlake Ave, Seattle, WA 98121, USA.
Vaccine: X
|August 28, 2023
概括
利益相关者在考虑对衰老和抗菌素耐药性的影响时优先考虑西格拉疫苗. 口服和组合疫苗是社区接受和纳入免疫计划的首选.
科学领域:
- 全球健康 全球健康
- 疫苗学 疫苗学 疫苗学
- 传染病流行病学 传染病流行病学
背景情况:
- 石格拉菌是儿童腹死亡的主要原因,具有潜在的长期发育影响.
- 目前还没有获得许可的Shigella疫苗,尽管候选疫苗正在开发中.
- 尽管西格拉疫苗在高风险国家具有重要公共卫生意义,但其优先级仍然不确定.
研究的目的:
- 确定国家和地区利益相关者对即将推出的西格拉疫苗的偏好和优先事项.
- 了解影响西格拉疫苗在免疫计划中的潜在引入因素.
主要方法:
- 这是一项混合方法研究,涉及亚洲和非洲五个国家的89个国家利益相关者和医疗保健提供者.
- 包括来自泛美卫生组织的区域利益相关者.
- 评估健康问题,疫苗偏好和优先考虑因素.
主要成果:
- 腹是五岁以下儿童最常提到的健康问题,但抗菌素耐药性 (AMR) 被利益相关者认为更令人担忧.
- 人们对西格拉菌的认识很高,但它并没有始终被视为主要的健康问题.
- 当考虑它们对减少衰老和AMR的影响时,利益相关者对西格拉疫苗的兴趣增加了,他们更喜欢口服/组合疫苗,而不是单抗原注射疫苗.
结论:
- 直接的利益相关者投入对于为西格拉疫苗开发和实施计划提供信息至关重要.
- 调查结果强调,需要将西格拉疫苗的好处范围超出了减轻腹的范围,以与利益相关者的优先事项保持一致.
- 了解疫苗格式和输送的偏好是成功引入常规免疫计划的关键.
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