适应偏振光声学计算机断层扫描用于生物异性质组织成像
Yang Zhang1, Christ Glorieux2, Shufan Yang3
1School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Photoacoustics
|August 28, 2023
概括
光声学计算机断层扫描 (PACT) 系统现在可以解释组织光学吸收异质性. 一种自适应偏光PACT (AP-PACT) 方法通过恢复丢失的信息和增强对比度来提高图像质量.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 摄影声学成像技术的成像
背景情况:
- 光声学计算机断层扫描 (PACT) 通常忽略了组织吸收异质性,导致图像数据不完整.
- 这种局限性阻碍了PACT在各种生物医学应用中的诊断潜力.
研究的目的:
- 为了研究光学吸收异质性对PACT图像质量的影响.
- 开发和验证一种自适应偏光PACT (AP-PACT) 方法,以解决信息丢失问题.
主要方法:
- 推导出光声响应与激发光极化角度之间的关系.
- 开发了一种适应性数据采集策略,使用光声响应的标准偏差作为反.
- 在幻影和体外样本上实施和测试AP-PACT方法.
主要成果:
- 通过AP-PACT方法,成功地恢复了与异型吸收相关的信息.
- 对于具有异型光学吸收的样品,可以实现最佳的图像对比度.
- 重建的PACT图像的质量得到了显著的改善.
结论:
- AP-PACT有效地弥补了由组织吸收异质性引起的成像信息缺乏.
- 这种新的方法通过提高图像质量,提高了PACT的诊断准确性和可靠性.
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