烟雾暴露与结石之间的关联:来自NHANES (2007-2018) 和孟德尔随机化分析的结果
Yong Huang1, Hexi Wang1, Chengwei Xu1
1Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in medicine
|August 28, 2023
概括
目前的吸烟和血清中高水平的丁氨酸与患结石的风险更高有关. 这项研究使用观测数据和孟德尔随机化分析探索了这种关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 烟雾暴露与结石 (结石) 风险之间的关联仍然存在争议.
- 调查这种联系对于公共卫生和临床实践至关重要.
研究的目的:
- 为了探索吸烟状态,血清丁度和结石病风险之间的关系.
- 为了确定血清中丁胺水平是否因果关系地影响结石风险.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据 (2007-2018) 的观察性研究.
- 统计分析包括后勤回归,趋势测试,限制立方线 (RCS) 和多重归算 (MI).
- 孟德尔随机化 (MR) 分析使用全基因组关联研究 (GWAS) 数据来评估因果关系.
主要成果:
- 目前吸烟者患结石的风险增加 (OR=1.17).
- 较高的血清胆氨酸水平 (≥0.05 ng/ml) 与结石风险增加有关 (趋势P<0.001).
- 核磁共振分析表明,基因预测的高血清胆固醇和增加结石风险 (OR = 1.09) 之间存在因果关系.
结论:
- 当前吸烟和血清中高丁度与患结石的风险更高有关.
- 这些发现表明存在潜在的因果关系,需要进一步调查机制.
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