莫马塔松富罗酸用于复发性腺增大:随机对照临床试验
Mohamed Mahmoud Roushdy1, Ahmed Aboulwafa Abdel Jalil2, Ahmed Mahmoud Saeed3
1Faculty of Medicine, Assiut University, Assiut, Egypt.
概括
局部使用的mometasone furoate可为患有复发性腺增大 (AH) 的儿童提供暂时的症状缓解,减少鼻腔阻塞. 然而,在停止治疗后,症状会复发,所有患者最终都需要进行腺切除术.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科呼吸系统医学 儿科呼吸系统医学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 腺体缩 (AH) 是儿童鼻腔阻塞的主要原因,导致各种呼吸道症状.
- 目前对AH的治疗主要涉及手术干预.
- 内类固醇在治疗过敏性鼻炎和相关的AH方面是有效的.
研究的目的:
- 评估局部用莫梅松酸盐在治疗儿科患者复发性腺增大时的疗效.
- 评估mometasone furoate对腺体大小和相关症状的影响.
主要方法:
- 一项随机对照试验,涉及39名儿童 (2-15岁) 患有复发性AH.
- 参与者被分为三个组:局部mometasone furoate,没有药物 (控制) 和局部正常液 (安慰剂).
- 治疗和随访持续时间为8周,随访时间延长以检查症状复发.
主要成果:
- 与对照组和安慰剂组相比,mometasone furoate在84.6%的患者中提供了暂时的症状缓解.
- 所有患者在停止服用mometasone furoate后都出现了AH症状的复发.
- 所有参与者最终在三个月的随访时间内都接受了腺切除术.
结论:
- 局部使用的mometasone furoate可以暂时减少腺的大小,并缓解儿童的相关症状.
- 莫梅酸的效果是暂时的,并且它不会消除在复发病例中需要进行腺切除术的需要.
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