在喉腔切除术后具有积极外科手术边缘的患者中,比较生存功能
Yılmaz Özkul1, Ejder Ciğer2, Mustafa Koray Balcı3
1Department of Otolaryngology-Head & Neck Surgery, Izmir Katip Celebi University, İzmir, Turkey.
概括
在喉癌中,积极的外科边缘 (PSM) 显著增加了复发和死亡风险. 实现负外科边缘 (NSM) 对于更好的无病生存 (DFS) 和整体生存 (OS) 至关重要.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 喉癌是一个重大的瘤挑战.
- 手术边缘是治疗成功的关键指标.
研究的目的:
- 根据手术边缘状态,比较喉癌患者的无疾病生存率 (DFS) 和整体生存率 (OS).
- 评估正外科边缘 (PSM) 与负外科边缘 (NSM) 的预后意义.
主要方法:
- 对46名喉癌患者的回顾性分析.
- 在PSM患者 (n=16) 和NSM患者 (n=30) 之间的DFS和OS的比较.
- 使用长等级测试进行生存分析.
主要成果:
- PSM是局部区域复发 (HR:1.6,p=0.004) 和与疾病相关的死亡率 (HR:3.2,p=0.002) 的独立风险因素.
- 患有NSM的患者表现出显著更长的DFS (p=0.001) 和OS (p=0.003).
- 2年和5年的DFS率为PSM的57%,相对于NSM的96%和83%,OS率为PSM的80%和34%,相对于NSM的96%
结论:
- 在喉癌中,积极的外科边缘与预后不佳密切相关.
- 达到负的外科手术边缘对于改善患者生存结果至关重要.
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