在慢性伤口中用于铁封存的酸自我交叉连接伤口包裹
Anastasia Anceschi1, Alessia Patrucco1, Parag Bhavsar1
1CNR-STIIMA, Italian National Research Council, Institute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing, Corso G. Pella 16, 13900 Biella, Italy.
ACS omega
|August 28, 2023
概括
一种新型的羊毛衍生酸伤口剂有效地结合了慢性伤口中多余的铁. 这种生物活性膜通过减少氧化应激和蛋白质分解性损伤来促进愈合,提供了一种新的治疗方法.
科学领域:
- 生物材料科学 生物材料科学
- 伤口治愈研究研究 伤口治愈研究
- 材料化学 材料化学
背景情况:
- 慢性伤害全球许多人,需要先进的治疗方法.
- 高水平的铁和蛋白质酶阻碍了慢性伤口愈合.
- 铁驱动氧化应激 (ROS),而蛋白酶会降解组织.
研究的目的:
- 开发一种新的生物活性伤口包裹,用于慢性伤口的铁结合.
- 为创建一个稳定的,羊毛衍生粉膜用于伤口应用.
- 评估带的铁封存能力和伤口愈合潜力.
主要方法:
- 制备了由羊毛衍生的角质膜,并进行了交叉连接以保持稳定性.
- 里叶变换红外 (FTIR),DSC和TGA分析了片的特性.
- 感应合等离子体光学发射光谱法 (ICP-OES) 测量了Fe3+吸附.
- QSAR工具箱在体测试中进行化学行为预测.
主要成果:
- 交叉链接的酸膜显示出显著的铁 (Fe3+) 吸附 (大约3倍). 85%) 的情况.
- 铁吸附遵循伪二阶动力学和粒子内部扩散模型.
- 在 silico 测试中预测了用于伤口愈合应用的有利化学行为.
结论:
- 酸盐生物活性敷料有效地扣留铁,减轻氧化损伤.
- 敷料起到激素清除作用,并降低了蛋白质分解活性.
- 这种新的生物材料促进组织再生,在慢性伤口护理方面提供了有前途的进展.
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