酒精消费和胰腺癌的发生率
Aage Tverdal1, Randi Selmer1, Dag S Thelle2,3
1Norwegian Institute of Public Health, PO Box 222, Skøyen, 0213 Oslo, Norway.
Global epidemiology
|August 28, 2023
概括
这项研究发现,高饮酒量与胰腺癌风险增加之间存在联系. 然而,这种关联可能是由于像吸烟习惯这样的混因素造成的.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 酒精摄入量与胰腺癌风险之间的关系尚不清楚.
- 之前的研究已经产生了关于酒精在胰腺癌发生中的作用的不一致的发现.
研究的目的:
- 调查酒精消费与胰腺癌发病率之间的联系.
- 探索这种关系中吸烟等潜在的混因素.
主要方法:
- 20至79岁的243169个人的一个大队伍被跟踪了20年.
- 胰腺癌发病率通过与国家癌症和死亡登记处的联系来确定.
- 考克斯的比例危险模型和曲线被用来分析酒精消费 (以每天玻璃单位) 和胰腺癌风险.
主要成果:
- 男性的多变量调整风险比为1.08 (95% CI 1.02-1.15) /玻璃单位/天,女性的多变量调整风险比为1.04 (95% CI 0.97-1.13).
- 酒精和胰腺癌之间的关联在现有和前吸烟者中都存在.
- 截面曲线表明,随着酒精消费的增加,胰腺癌的风险增加,可信度波段不包括每天超过1个玻璃单位的1.0.
结论:
- 较高的酒精消费与发生胰腺癌的风险增加有关.
- 观察到的关联可能会被吸烟习惯所混.
- 需要进一步的研究,以充分阐明酒精在胰腺癌发展中的作用,考虑到吸烟是重要的混因素.
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