迷失在树林里:在系统审查中找到回归科学方法的方法
Heather N Lynch1, Kenneth A Mundt1, Dirk Pallapies2
1Stantec ChemRisk, Boston, MA, United States of America.
Global epidemiology
|August 28, 2023
概括
系统审查方法对于化学品风险评估和监管决策至关重要. 通过国际合作协调这些方法对于客观证据综合和人类健康风险评估至关重要.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 监管科学 监管科学
背景情况:
- 系统性审查对于监管决策中的因果关系评估越来越重要,包括化学风险评估.
- 标准化系统审查方法仍然是一个挑战,尽管它们具有客观性和透明性的潜力.
- 美国和欧洲现有的框架需要协调,以确保一致可靠的证据综合.
研究的目的:
- 总结系统审查方法的演变.
- 评估和比较美国环境保护局 (EPA) 的系统审查框架.
- 为协调系统审查方法提出前进的路径.
主要方法:
- 审查系统审查的发展和当前的框架在美国和欧洲.
- 对两个美国环保署系统审查框架的深入比较分析.
- 纳入美国国家科学,工程和医学院的建议.
主要成果:
- 系统审查方法已经有了很大的进步,但缺乏标准化.
- 美国环保署框架为系统审查提供了不同的方法.
- 需要国际合作来制定一个协调的系统审查蓝图.
结论:
- 对个别框架的进一步批评是无效的;需要一种协作式的方法.
- 国际努力应集中在一个蓝图上,该蓝图整合了可适应特定目的的科学关键元素.
- 协调的系统审查方法将加强对全球健康问题的科学证据的客观评估.
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