职业农药暴露对人类肠道微生物群的影响
Milla F Brandao Gois1, Asier Fernández-Pato1, Anke Huss2
1Department of Genetics and Department of Gastroenterology and Hepatology University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Frontiers in microbiology
|August 28, 2023
概括
职业接触农药,包括杀虫剂和杀菌剂,显著改变人类肠道微生物群. 这项研究揭示了微生物多样性和细菌种群的变化,突出了健康影响.
科学领域:
- 环境健康 环境健康
- 微生物学 微生物学
- 职业健康 职业健康 职业健康
背景情况:
- 农业中农药的使用正在增加,将疾病负担转移到化学物质暴露.
- 人的肠道微生物组在代谢环境污染物和异生菌中发挥着作用.
- 了解职业农药暴露对肠道微生物群的影响对于健康洞察至关重要.
研究的目的:
- 研究职业农药暴露对人类肠道微生物组合的影响.
- 为了确定特定的农药类别和肠道微生物变化之间的关联.
主要方法:
- 来自荷兰微生物组项目 (生命线研究) 的7198名参与者的分析.
- 使用职业暴露矩阵和职业代码进行农药暴露评估 (一般农药,除草剂,杀虫剂,杀菌剂).
- 检查了农药暴露与肠道微生物群多样性 (α和β) 和细菌种群丰度之间的关联.
主要成果:
- 对杀虫剂,杀菌剂和一般杀虫剂的职业暴露与肠道微生物α多样性降低有关.
- 在暴露于农药的个体中观察到肠道微生物β多样性的显著差异.
- 39种细菌种群的丰富性变化与接触各种类型的农药有关.
结论:
- 职业农药暴露对人类肠道微生物组的组成和多样性产生重大影响.
- 这些发现强调了农药作为影响肠道微生物生态的环境污染物的作用.
- 需要进一步的研究来阐明与农药诱导的肠道微生物组改变相关的健康机制.
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