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肠道微生物群和脑血管疾病:一种门德尔的随机化研究

Hao Qin¹, Fan Yang², Pengfei Hao³

¹Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China.

Frontiers in microbiology

|August 28, 2023

概括

肠道微生物群的组成因果关系地影响了脑血管疾病的风险. 系统血压和2型糖尿病等代谢因素可能会调解这些效应,突出显示潜在的治疗点.

科学领域:

遗传学遗传学是一个
微生物学微生物学
流行病学流行病学

背景情况:

肠道微生物群和脑血管疾病之间的联系尚不清楚.
最近的研究表明存在关联,但因果关系需要进一步调查.

研究的目的:

调查肠道微生物群和脑血管疾病之间的因果关系.
确定影响脑血管疾病风险的特定细菌种群.
检查系统血压 (SBP),2型糖尿病 (T2D) 和体重指数 (BMI) 的调解作用.

主要方法:

使用全基因组关联研究 (GWAS) 总结统计数据进行双样本孟德尔随机化 (MR) 分析.
反向MR分析以评估双向因果关系.
两个步骤的MR评估SBP,T2D和BMI的调解.
敏感性分析以确保结果的可靠性.

主要成果:

高丰富的Porphyromonadaceae家族细菌与减少内动脉瘤风险有关.
在17个肠道微生物群和内动脉瘤之间发现了名义上的因果关系.
13到8种肠道细菌显示了与中风及其亚型的因果关系.
遗传预测性中风 (AS,AIS) 减少了Clostridiaceae和Clostridiales的丰富性.
链球菌属的影响是由T2D调解的; Eubacterium支臂菌群的影响是由SBP.

结论:

肠道微生物群的组成对脑血管疾病有因果影响,无论是有益的还是有害的.
系统性血压和2型糖尿病被确定为肠道微生物群-脑血管疾病轴的潜在媒介.

关键词:

门德尔的随机化因果关系影响因果关系影响.我们的肠道微生物组.内动脉瘤内动脉瘤一次性中风中风中风中风中风

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