对长期阿片类药物戒断综合征的针相关疗法:系统性审查和元分析
Lu Ding1, Cui Li1, Peiming Zhang2
1Clinical Research and Big Data Laboratory, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China.
Integrative medicine research
|August 28, 2023
概括
针可以有效地减少长期阿片类药物戒断综合征 (POAS) 戒断症状. 然而,证据质量受到包含试验中的高偏差的限制,这需要谨慎地解释结果.
科学领域:
- 综合医学是一个整体的医学.
- 疼痛管理 疼痛管理
- 成精神病学成精神病学
背景情况:
- 越来越多的临床证据表明,针对长期阿片类药物戒断综合征 (POAS) 的疗效.
- 这项研究系统地审查和评估了针治疗POAS有效性的证据.
研究的目的:
- 评估针和相关疗法的治疗或预防POAS的疗效.
- 综合了POAS针随机临床试验 (RCT) 的研究结果.
主要方法:
- 在2022年3月31日之前搜索了主要的英语和中文数据库 (PubMed,Medline,Embase,Cochrane,CNKI,WanFang,VIP).
- 包括评估POAS针的RCT,评估主要结果 (阿片类戒断表) 和次要结果 (抑郁症,焦虑症).
- 使用Cochrane偏差风险工具评估RCT质量.
主要成果:
- 在分析中包括了28个RCT;只有3个 (11%) 的偏差风险低.
- 与针相关的治疗显著改善了与假针,西方医学和没有治疗 (高异质性) 相比,戒断症状得分.
- 在戒断症状,抑郁和焦虑的改善方面观察到统计学意义.
结论:
- 针似乎是安全和有效的缓解持久的戒断症状在POAS个体.
- 由于在包含的试验中发现的偏差高风险,研究结果应谨慎解释.
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