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从器官保存到选择性手术:免疫疗法如何改变结直肠手术?

Shiya Yao¹, Huanrong Lan², Yuejun Han¹

¹Department of Colorectal Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang 321000, China.

Surgery open science

|August 28, 2023

概括

免疫疗法,特别是免疫检查点封锁,正在改变结肠直肠癌 (CRC) 治疗. 突破使MSI-H/dMMR患者的器官保存成为可能,这表明选择性手术方法可以获得更好的结果.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
结肠直肠癌研究研究

背景情况:

免疫疗法显著改变了常规结直肠癌 (CRC) 治疗策略.
免疫检查点阻塞现在是转移性CRC (mCRC) 的标准一线治疗方法,并且在局部晚期CRC (LACRC) 中表现有前途.

研究的目的:

审查最近的临床试验,证明结直肠癌免疫疗法的突破.
突出MSI-H/dMMR瘤患者器官保存方面的进展.
基于这些发现,提出选择性手术的概念,包括淋巴结管理.

主要方法:

对专注于结直肠癌免疫治疗的临床试验的系统审查.
对治疗结果的分析,特别是MSI-H/dMMR患者队列中的器官保存率.
基于免疫治疗反应的选择性手术策略的概念化.

主要成果:

在免疫疗法,特别是免疫检查点阻塞方面取得了重大进展,用于mCRC和LACRC.
在接受免疫治疗的高微卫星不稳定性或DNA不匹配修复缺陷 (MSI-H/dMMR) 患者中,器官保存方面的突破显而易见.
这些进展支持开发新的治疗模式.

结论:

免疫疗法为特定结直肠癌亚型的器官保存提供了新的可能性.
选择性手术的概念,涉及量身定制的淋巴结管理,需要进一步调查.
未来的研究应该专注于验证这些选择性手术方法以优化CRC治疗.

关键词:

结肠直肠癌是一种癌症.免疫治疗是一种免疫疗法.局部发达的直肠癌局部发达的直肠癌淋巴结的追踪淋巴结的追踪器官的保存器官的保存选择性手术是一种选择性手术.

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