versaFlow:用于调整分辨率的扩散核磁共振处理的多功能管道,及其应用在研究PRIME-DE数据库的可变性方面
Alex Valcourt Caron1, Amir Shmuel2, Ziqi Hao2
1Sherbrooke Connectivity Imaging Laboratory, Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada.
Frontiers in neuroinformatics
|August 28, 2023
概括
我们开发了versaFlow,这是一个强大的管道,用于分析非人类灵长类动物的扩散MRI数据. 该工具解决了验证挑战,并揭示了扩散指标的显著变化,突出了协调的必要性.
科学领域:
- 神经成像是一种神经成像.
- 生物医学工程 生物医学工程
- 计算神经科学是一种神经科学.
背景情况:
- 验证扩散加权成像 (DWI) 是一个挑战,因为没有黄金标准.
- 翻译分析,比较人类和动物数据,是一种常见的验证方法.
- 非人类灵长类动物 (NHP) 是有价值的模型,因为它们的细胞架构与人类相近,但需要专门的成像工具.
研究的目的:
- 推出versaFlow,一个可扩展和强大的Nextflow管道用于在体内处理NHP DWI数据.
- 分析灵长类数据交换 (PRIME-DE) 数据集中的扩散指标的可变性.
- 为了评估versaFlow管道的可重复性.
主要方法:
- 开发了versaFlow,一个使用最先进的MRI处理和扩散建模 (DTI,CSD,DIAMOND) 的模块化管道.
- 从PRIME-DE数据集 (32个受试者,3个站点,不同的分辨率和获取参数) 获取到NHP DWI数据.
- 使用来自艾克斯-马赛站点的数据进行了一项可复制性研究.
主要成果:
- 对大多数扩散指标来说,versaFlow表现出高的可重复性.
- 由于软件限制,DIAMOND的马分布参数显示出较低的可重现性.
- PRIME-DE数据集在扩散指标中表现出相当大的变化,与人类研究的变化相当或超过.
结论:
- versaFlow是一个可定制和可扩展的管道,用于NHP DWI分析.
- 显著的数据变化需要仔细的统计分析,并表明需要采购协调.
- 未来的研究应该考虑强大的算法来管理NHP成像中的跨扫描仪和跨供应商变化.
相关概念视频
01:24Magnetic Resonance Imaging
5.2K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
5.2K
01:17Assessment of Diffusion and Perfusion
1.0K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.0K