在COVID-19之后发生自身免疫性疾病的风险和疫苗接种的潜在保护作用:基于人口的队列研究
Kuan Peng1,2, Xue Li1,2,3, Deliang Yang1
1Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
EClinicalMedicine
|August 28, 2023
概括
感染COVID-19会增加患自身免疫性疾病的风险. 然而,接收两剂COVID-19疫苗可以降低感染后某些自身免疫疾病的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 类风湿病学 类风湿病学
背景情况:
- 新出现的证据表明,SARS-CoV-2感染可能会引发免疫失调和自身免疫.
- 确立了COVID-19疫苗接种在预防严重的COVID-19结果方面是有效的.
- COVID-19,随后的自身免疫性疾病发展和疫苗疗效之间的关系需要进行调查.
研究的目的:
- 调查COVID-19感染与自身免疫性疾病 (ADS) 发生率之间的关联.
- 评估COVID-19疫苗接种对感染后新发性ADs发展的潜在保护作用.
主要方法:
- 香港的回顾性队列研究 (2020年4月 - 2022年11月),包括超过100万名COVID-19患者和300万名对照.
- 通过PCR或快速抗原测试确认COVID-19诊断.
- 考克斯比例危险回归与治疗权重的逆概率被用于评估AD风险和疫苗效应.
主要成果:
- 在COVID-19患者中,患有恶性贫血,脊椎关节炎,类风湿性关节炎,牛皮,皮,格雷夫斯病,抗脂抗体综合征,免疫媒介性血小板缩,多发性硬化和血管炎的风险增加.
- 在COVID-19患者中,用两剂COVID-19疫苗接种疫苗与皮病,格雷夫斯病,抗脂抗体综合征,免疫媒介性血小板缩,全身性红斑狼和其他自身免疫性关节炎的风险降低有关.
结论:
- COVID-19 感染与患各种自身免疫性疾病的风险更高有关.
- 接种COVID-19疫苗,特别是完成初级系列,可能会减轻这种增加的风险.
- 对潜在的病理机制进行进一步研究是有必要的.
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