爱斯坦-巴尔病毒感染和乳腺癌风险:系统性审查
Arjola Agolli1, Angela Ishak2, Mahima Viswanathan3
1Pennsylvania State University, College of Medicine, Hershey, USA.
概括
爱斯坦巴尔病毒 (EBV) 感染可能会增加女性患乳腺癌的风险,尤其是侵袭性乳腺癌. 这一系统性审查发现EBV在27.9%的乳腺癌病例中存在,而对照组的EBV为8.02%.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 乳腺癌是全球领先的癌症,患病率越来越高.
- 爱斯坦巴尔病毒 (EBV) 已广泛传播,但其与包括乳腺癌在内的癌症严重程度的联系尚未完全理解.
- 经由HER2/HER3信号传递或慢性免疫刺激,EBV可能会导致乳腺癌.
研究的目的:
- 系统地审查和评估乳腺癌患者先前感染爱斯坦巴尔病毒 (EBV) 的患病率.
- 评估EBV与乳腺癌风险之间的关联.
主要方法:
- 在主要的电子数据库 (PubMed,ScienceDirect等) 进行了系统的文献搜索. ) 的情况.
- 该审查遵循了系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 包括24项病例控制研究,分析了1,989例乳腺癌病例和1,034例对照.
主要成果:
- 爱斯坦巴尔病毒 (EBV) 在27.9%的乳腺癌病例中被检测到,而对照组织中为8.02%.
- 在EBV感染组织中观察到的最常见的乳腺癌类型是侵入性乳腺癌.
- 患病率在地理位置上有所不同 (4.6%64.1%),影响女性的平均年龄为48.19岁.
结论:
- 以前的爱斯坦巴尔病毒 (EBV) 感染似乎与乳腺恶性瘤的风险增加有关,主要是侵入性类型.
- 调查结果强调了地理差异和对女性的主要影响.
- 需要进一步的研究来澄清EBV在乳腺癌机制中的作用,并为预防/治疗策略提供信息.
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